England will look to build on their narrow win over Wales in the Six Nations last time out by beating Scotland in their backyard and claim the Calcutta Cup.
Steve Borthwick‘s side made it two wins from two and are sitting second behind Ireland in the table.
The home side trailed by nine points at the break against Wales but sealed a hard-fought win late on thanks to George Ford’s penalty.
Meanwhile, Scotland nearly blew a huge lead over Wales in their first game before losing to France.
However, a win here would give the Scots a chance of winning the Six Nations, so we are all set for a big clash.
Scotland vs England: Date and how to follow
This Six Nations match will take place on Saturday, February 24.
Play at Murrayfield in Edinburgh is due to start at 4:45pm.
The match will be broadcast on BBC One and iPlayer.
talkSPORT will have Chris Egerton in Scotland providing updates and talkSPORT.com will have all the reaction.
To tune in to talkSPORT or talkSPORT 2 through the website, click HERE for the live stream. You can also listen via the talkSPORT app, on DAB digital radio, through your smart speaker and on 1089 or 1053 AM.
Scotland vs England: Team news
The hosts have recalled Hamish Watson to help the back row, while Blair Kinghorn and WP Nel are back to full fitness.
Josh Bayliss will play no part due to concussion, while Javan Sebastian and Ross McCann have dropped out.
Meanwhile, England are prepared to welcome Manu Tuilagi back from a groin injury.
Marcus Smith and Ollie Lawrence are also edging towards full fitness.
Scotland squad
Forwards: Ewan Ashman, Magnus Bradbury, Jamie Bhatti, Alex Craig, Andy Christie, Scott Cummings, Jack Dempsey, Rory Darge, Grant Gilchrist , Matt Fagerson, Zander Fagerson, Alec Hepburn, Johnny Matthews, Elliot Millar-Mills, WP Nel, Jamie Ritchie, Pierre Schoeman , Sam Skinner, George Turner, Hamish Watson, Glen Young.
Backs: Ben Healy, George Horne, Rory Hutchinson, Huw Jones (Glasgow), Blair Kinghorn (Toulouse), Stafford McDowall, Harry Paterson, Ali Price, Cameron Redpath, Arron Reed, Kyle Rowe, Finn Russell, Kyle Steyn, Ross Thompson, Sione Tuipulotu, Duhan van der Merwe, Ben White.
England squad
Forwards: Ollie Chessum, Dan Cole, Alex Coles, Luke Cowan-Dickie, Chandler Cunningham-South, Ben Curry, Theo Dan, Alex Dombrandt, Ben Earl, Charlie Ewels, Ellis Genge, Jamie George (capt), Joe Heyes, Maro Itoje, Joe Marler, Beno Obano, George Martin, Ethan Roots, Will Stuart, Sam Underhill.
Backs: Danny Care, Elliot Daly, Fraser Dingwall, Immanuel Feyi-Waboso, George Ford, Tommy Freeman, George Furbank, Alex Mitchell, Will Muir, Max Ojomoh, Tom Roebuck, Henry Slade, Fin Smith, Ben Spencer, Freddie Steward, Manu Tuilagi.
Scotland vs England: What has been said?
Scotland head Gregor Townsend has admitted that back-to-back wins over England at Twickenham are some of the biggest in his career.
He said: “2021 is one of the best wins I’ve been involved in whether as a supporter, player or a coach.
“It was just one of those great days when the team won through playing rugby and also defending really well. It was a very well-deserved victory and it inspired and engaged our supporters.
“We didn’t grind it out, we didn’t win by two points, we won by playing excellent rugby and continuing that in a physical second half.
“But last year, meant so much to me from a personal point of view – I thought it was going to be my last Six Nations, so I was probably more emotional after that game than others I’ve coached.”