George North returns from injury to play for Wales against England at Twickenham on Saturday as one of seven changes to the team beaten by Scotland.
The fit-again centre will be making his 50th Six Nations appearance.
Ioan Lloyd and Tomos Williams, who helped spark last weekend’s comeback in the 27-26 defeat by Scotland, are rewarded with starts.
The entire starting front-row changes with Gareth Thomas, Elliot Dee and Keiron Assiratti all selected.
Flanker Alex Mann, who scored a try against Scotland, gets his first Test start.
It is a first Test start at fly-half for Lloyd while Dafydd Jenkins continues as captain.
Scrum-half Gareth Davies is dropped from the matchday squad while Owen Watkin makes way for North. Sam Costelow (neck), Leon Brown (shoulder) and James Botham (knee) are injured.
Prop Corey Domachowski and hooker Ryan Elias step down to a bench that includes uncapped Bath tight-head prop Archie Griffin.